The Gonzaga protected art and culture, and hosted several important artists like Leone Battista Alberti, Andrea Mantegna, Giulio Romano, Donatello, Peter Paul Rubens, Pisanello, Domenico Fetti, Luca Fancelli and Nicolò Sebregondi. Though many of the masterworks have been dispersed, the cultural value of Mantua is nonetheless outstanding. Many monuments furnish examples of unique patrimony in patrician buildings and Italian architecture.

Main monuments include:

• The Palazzo Te (1525-1535), a creation of Giulio Romano (who lived in Mantua in his final years) in the style of mature Renaissance and with some hints of a certain post-Raphaelian mannerism. It was the summer residential villa of Frederick II of Gonzaga. It hosts the Museo Civico (with the donations of Arnoldo Mondadori, one of the most important Italian publishers, and Ugo Sissa, a Mantuan architect who worked in Iraq from where he brought back important Mesopotamian artworks).
  
  
• The Palazzo Ducale, famous residence of the Gonzaga family, made up by a number of buildings, courtyards and gardens gathered around the Palazzo del Capitano, the Magna Domus, and the Castle of St. George.
  
  
• Other important monument in Mantua are:
  
  
• The Basilica of Sant'Andrea
• The Duomo
• The Rotonda di San Lorenzo
• The Bibiena Theater
• The Church of San Sebastiano
• The Palazzo Vescovile ("Bishops Palace")
• The Palazzo degli Uberti
• The Torre della Gabbia ("Cage Tower")
• The Palazzo del Podestà that hosts the museum of Tazio Nuvolari
• The Palazzo della Ragione with the Torre dell'Orologio ("Clock Tower")
• The Palazzo Bonacolsi